Siga launches clinical study for TPOXX IV formulation

BioPrep Watch

Siga Technologies Inc., a company that focuses on the creation and sale of solutions for biodefense and medical needs with unmet problems, recently launched its phase-one single ascending dose clinical study for TPOXX in an intravenous (IV) formulation.

TPOXX is the top drug candidate at the company. It is designed to treat orthopoxvirus diseases. To conduct the study, Siga collaborated with the Biomedical Research and Development Authority (BARDA).

The purpose of the study is to determine the safety and pharmacokinetic value of developing a protocol for the company’s next phase-one clinical trial within its IV program. The next phase is a multiple ascending dose safety as well as pharmacokinetic trial.

“This collaboration with BARDA on an IV formulation is an important step toward realizing the full capability of TPOXX,” Siga CEO Eric Rose said. “This trial advances our efforts to ensure better protection of Americans from a smallpox outbreak.”

Siga’s ultimate goal within its IV program is to develop formulations of IVs that can be used as alternative treatments for people who have dysphagia. It will also be useful for patients who are seriously sick, hospitalized or cannot swallow the traditional oral capsules.


Siga Technologies, Inc.660 Madison AveNew York, NY 10173

One thought on “Siga launches clinical study for TPOXX IV formulation

  1. Well in my old way of thinking, any one attempting to break in and steal my property risks being damaged. ie. shot. I know an old viet nam vet that uses the garage detached from the house as his bedroom. He keeps a loaded 12 Ga. shotgun readily available and he has a defensive/offensive attitude. Any bugler type needs to be removed from society. This would demonstrate to other criminals that doing such things exposes you to a death penalty immediately carried out! Any one brazen enough to attempt a breakin to some elses private property should be deemed to be an immediate approximate threat of life and limb and death with accordingly. If I let him escape will he go to my sons house next to me and this time break in their house and do mayhem? Police shoot people in the back all of the time. This is a double standard re: justice.. If I were this guys attorney I’d go with this argument. Doug

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