In the study to investigate the effects of pesticides containing different adjuvants like Roundup formulations found in the environment, surface waters and as food residues of Roundup tolerant genetically modified plants on cells from liver, a major detoxification organ, and the mechanism of action and possible protection by precise medicinal plant extracts called Dig1
(plant extracts from Taraxacum offici-nalis, Arctium lappa andBerberis vulgaris), by the research team lead by Dr. Céline Gasnier, found that all the four Roundup (four formulations of glyphosate-based herbicides, Express® 7.2 g/l of G called glyphosate or N-(phosphonomethyl) glycine, product number 2010321;Bioforce® 360 g/l of G, product number 9800036; GT® 400g/l of G, product number 8800425; GT+® 450 g/l of G,product number 2020448) formulations provoke liver cell death, with adjuvants having stronger effects than glyphosate alone.
Hep3B are 3-5 times more sensitive over 48 h. Caspases 3/7 are greatly activated in HepG2 by Roundup at non-cytotoxic levels, and some apoptosis induction by Roundup is possible together with necrosis.CYP3A4 is specifically enhanced by Roundup at doses 400 times less than used in agriculture (2%).
CYP1A2 is increased to a lesser extent together with glutathione-S-transferase (GST) down-regulation. Dig 1, non cytotoxicand not inducing caspases by itself, is able to prevent Roundup-induced cell death in a time-dependant manner with an important efficiency of up to 89%, within 48 h.
In addition, we evidenced that it prevents Caspases 3/7activation and CYP3A4 enhancement, and not GST reduction, but in turn it slightly inhibited CYP2C9 when added before Roundup and concluded that Roundup is able to provoke intracellular disruption in hepatic cell lines at different levels, but a mixture of medicinal plant extracts Dig1 can protect to some extent human cell lines against this pollutants. All this system constitutes a tool for studying liver intoxication and detoxification(1).
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