A team of University of Notre Dame researchers led by Mayland Chang and Shahriar Mobashery have discovered a new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus(MRSA) and other drug-resistant bacteria that threaten public health. Their research is published in the Journal of the American Chemical Society in an article titled “Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity.”
The new class, called oxadiazoles, was discovered in silico (by computer) screening and has shown promise in the treatment of MRSA in mouse models of infection. Researchers who screened 1.2 million compounds found that the oxadiazole inhibits a penicillin-binding protein, PBP2a, and the biosynthesis of the cell wall that enables MRSA to resist other drugs. The oxadiazoles are also effective when taken orally. This is an important feature as there is only one marketed antibiotic for MRSA that can be taken orally.
MRSA has become a global public-health problem since the 1960s because of its resistance to antibiotics. In the United States alone, 278,000 people are hospitalized and 19,000 die each year from infections caused by MRSA. Only three drugs currently are effective treatments, and resistance to each of those drugs already exists.
The researchers have been seeking a solution to MRSA for years. “Professor Mobashery has been working on the mechanisms of resistance in MRSA for a very long time,” Chang said. “As we understand what the mechanisms are, we can devise strategies to develop compounds against MRSA.”
“Mayland Chang and Shahriar Mobashery’s discovery of a class of compounds that combat drug resistant bacteria such as MRSA could save thousands of lives around the world. We are grateful for their leadership and persistence in fighting drug resistance,” said Greg Crawford, dean of the College of Science at the University of Notre Dame.
The above story is based on materials provided by University of Notre Dame. Note: Materials may be edited for content and length.
- Peter I. O’Daniel, Zhihong Peng, Hualiang Pi, Sebastian A. Testero, Derong Ding, Edward Spink, Erika Leemans, Marc A. Boudreau, Takao Yamaguchi, Valerie A. Schroeder, William R. Wolter, Leticia I. Llarrull, Wei Song, Elena Lastochkin, Malika Kumarasiri, Nuno T. Antunes, Mana Espahbodi, Katerina Lichtenwalter, Mark A. Suckow, Sergei Vakulenko, Shahriar Mobashery, Mayland Chang.Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity. Journal of the American Chemical Society, 2014; 136 (9): 3664 DOI: 10.1021/ja500053x
6 thoughts on “New class of antibiotics discovered by chemists”
This is all we need is another anti biotic. 🙁
They only test chemicals that can be patented and make the pharmaceuticals billions of dollars. They never test things they cannot make money off of, like colloidal silver or lyposomal vitamin C.
more money in the drug company coffers, while the people that buy the stuff dye from the complications that these so called medications will cause.
I guess the old class of antibiotics weren’t getting people sick enough.
I purchased a jar of the Manuka honey and it works great against all bacteria skin infections including MRSA who needs an antibiotic. Look it up.
Yea Sue I have some of that. very good stuff.